Ease your dog into a new routine
Dogs that normally spend their day playing with kids and being stimulated with people around them, can experience anxiety when they are suddenly left alone. Set your alarm a bit earlier and bring your dog outside for toilet and a vigourus walk or home training session to tire them out. Start setting meal times to this new routine too.
Slowly get them used to being alone
Ease your dog into being left alone slowly. Start with 20 minutes and build up to longer periods, baring in mind dogs need to go potty every 4 hours or so. This will teach your dog to spend time alone and be calm and stress free.
Enrichment activities
I wrote a couple of posts about enrichment toys here and these could help you keep the dog busy for a while. A bored dog can be a destructive dog so get your thinking cap on and get some interactive toys.
Doggy Day Care / Dog Walker
If you have to leave your dog home for extended periods of time perhaps dropping them off at a doggy day care a few times a week could help. Another option could be a local dog walker who visits your dog once a day for a walk and a bit of playtime.
Background / White noise
I always leave my radio on for the dog whenever I leave the house as that's what is normal whenever I am around. If you have a noisy house then an empty quiet house can be strange for your dog. Trial leaving on the TV or radio when you’re away to see if it makes a positive difference for your dog.
It may take a couple of weeks but dogs are very adaptable so just be patient with your pooch while they get used to their new routine.